Sherri's first client was "Macho Man" Randy Savage. Sherri began managing Savage after he was defeated by Hulk Hogan at Wrestlemania 5. They had several battles with Hogan, including the main event at Summerslam 89, but were unable to win the WWF title back from him. Shortly after this, Savage beat Hacksaw Jim Duggan to become the "King" of the WWF. Savage and Sherri were crowned King and Queen of the WWF at an in-ring coronation ceremony. Sherri and Savage went on to fued with "The American Dream" Dusty Rhodes and his manager, "Sweet" Sapphire. They battled in the first ever mixed tag match at Wrestlemania 6.
After dealing with Rhodes and Sapphire, The royal couple turned their attention to the new WWF champion, The Ultimate Warrior. Savage and Warrior fought a "retirement" match at Wrestlemania 7. When Savage lost the match, Sherri became enraged and began beating on Randy Savage. His former manager, Miss Elizabeth, ran down to the ring and tossed Sherri from the ring. Sensational Sherri had lost her position as queen and was forced to find a new man.
Her new man was Ted Dibiase, also known as the "Million Dollar Man." She managed him through the rest of 1991 and helped him in his feud with his former bodyguard, Virgil. Sherri then moved on to guide Shawn Michaels as he began his singles career after the breakup of his friendship with his tag team partner, Marty Janetty.
After managing Michaels, Sensational Sherri left the WWF and went to WCW where she managed the World Champion, Ric Flair. She changed her name to "Sensuous" Sherri and soon began helping Flair in another feud with Hulk Hogan. When Flair lost a retirement cage match against Hogan at Halloween Havoc 94, Sherri was forced to find new clients. This time, she managed Booker T and Stevie Ray, known as Harlem Heat. She guided them to the WCW tag team titles and called herself "Sister" Sherri. In 1997, Sherri left WCW and spent some time on the Independent Curcuit, mostly as a villainess. She was inducted into the WWE Hall of Fame in 2006.