The first villainess to take on DC's premiere superteam solo, in Justice League of America #23, Zazzala was an alien from the planet Korll. Introduced into the DC Universe by Gardner Fox, Mike Sekowsky and Bernard Sachs, she commanded a drone army and planted a bomb at the Earth's core to force the heroes to find potions that would make her immortal. It worked, though it also forced her into comatose immobility.
She shrugged that off to return several more times, but it wasn't until Grant Morrison recreated her, as part of his new Injustice Gang of the World in JLA #36 [1999], that she became a world-class threat. Much more insectoid then before, she converted New York City into a huge hive and its population into drones.
Morrison even threw a little entomology in; though seemingly unstoppable, he bee-like inability to recognize the color red brings about her defeat.