Poison Ivy appears as a playable character in Injustice 2, once again voiced by Tasia Valenza. In the game's story mode, she allies herself with the Society to take over the planet, disappointed that Batman's reform from the Regime wasn't environmentally friendly. She battles her fellow Gotham City Sirens, Harley Quinn and Catwoman (or Cyborg depending on who the player chooses). In her single player ending, Poison Ivy makes Brainiac collect every city on Earth, then kisses Brainiac, killing the Coluan with her poison. She then uses the Earth's plant life to rule the planet.
- Poison Ivy was based on the comic character of the same name.