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Milissa Wilcox, aka The Witch of Salem (Janet Waldo; 1920-2015) is the main villainess from "To Switch a Witch," episode 3.04 of The Scooby Doo Show (airdate September 30, 1978).

In actuality, the Witch is the disguise of Arlene Wilcox's evil twin sister (whose name isn't revealed), as she plotted to take over Wilcox estate, which Arlene inherited. Milissa Wilcox was an ancestor of Arlene and her sister, and she was notoriously burned at the stake and accused of witchcraft. Arlene's twin used the legend to disguise herself as Milissa's ghost and scare the people of Salem into believing that Arlene is possessed by the witch. She bribed town squire Gar Mooney into colluding with her in her evil scheme.

Despite the gang's original trap failing, the villainess ended up caught when she fell into an open grave. After getting a good look at the witch, Arlene was shocked to discover the villainess' resemblance to her, and it was revealed that she was her long lost twin sister. After the reveal, Arlene's evil twin and Gar Mooney were both taken to jail.

Nothing much is known about Arlene's twin. Judging on that Arlene had no recollection of having a twin, suggesting that the sisters were separated when they were very young. In the family tree their parents are listed as Warren Wilcox and Jane Putnam. It may also be the case that she isn't actually Arlene's real sister, just looking to be taking advantage of it to act incognito and let Arlene take the blame for everything, since unlike other villains, she wasn't unmasked after being captured .

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