Melisha Tweedy, better known as Mrs. Tweedy, is the main antagonist of DreamWorks' 4th full-length animated feature film Chicken Run, which is Aardman's 1st feature film. She is Mr. Tweedy's wife and boss, and Ginger's arch-nemesis.
She was voiced by Miranda Richardson, who also played Lady Van Tassel in the 1999 live action horror film Sleepy Hollow.
In the 1950's, a chicken named Ginger (the heroine of the film) made several failed attempts for her and her fellow chickens to escape from Mrs. Tweedy's farm in Yorkshire, England. As it turns out, Mrs. Tweedy runs the farm like a concentration camp, forcing the chickens to produce eggs to sell for profit and killing those who failed to produce any eggs for a week. As the year goes by, Mrs. Tweedy discovers that profits are constantly going down due to low amounts of eggs being laid. Her husband Mr. Tweedy correctly suspects the chickens are "up to something" due to their attempts to escape, but Mrs. Tweedy brushes this off, believing that they (apart from Mr. Tweedy) are the stupidest creatures on the planet. After seeing an ad for a pie machine, Mrs. Tweedy decides to purchase it to turn all of her chickens into pies in a bid to increase her profits.
After purchasing the machine, Mrs. Tweedy and her husband attempt to kill Ginger in their machine in order to test it, but are thwarted when a visiting American rooster named Rocky rescues her and clogs the gravy sprayer, almost destroying the machine. The chickens begin to prepare their ultimate escape plan: creating an airplane out of their sheds to fly off the farm. In the meantime, Mrs. Tweedy forces Mr. Tweedy to fix the machine. After the repairs are done, Mrs. Tweedy tells Mr. Tweedy to fetch all of the chickens. However, Mr. Tweedy finds out that most of his tools were stolen for the chickens' plan, but he is attacked by the chickens and tied up. He attempts to warn Mrs. Tweedy about this, but she ignores him, unaware of what is going on.
Just as Ginger is about to set up the ramp to help the airplane fly off, Mrs. Tweedy tries to stop her with her axe, finally seeing what's really going on. Fortunately, Rocky (who left until he saw an advertisement for Mrs. Tweedy's Chicken Pies) returns and uses his bike to knock Mrs. Tweedy unconscious, accidentally throwing the axe in the air. Mrs. Tweedy came to and sees the axe land right next to her neck, making her pass out again due to the shock. With that in mind, Rocky and Ginger set the ramp before escaping with the other chickens in their plane.
However, Mrs. Tweedy wakes up and goes off in pursuit of the escaping chickens by grabbing onto the dragging rope. Now insanely mad, she climbs herself up to stop the plane, even if it means endangering her own life. Fortunately, Ginger tricks Mrs. Tweedy into cutting the rope with her axe, and she lands in the safety valve of the pie machine, causing it to explode due to the overwhelming pressure that the gravy has caused, destroying much of the barn.
Despite having survived the explosion, Mrs. Tweedy finds herself covered in gravy and stuck inside the same pipe detached from the machine by the explosion. As the chickens have finally escaped from the farm, Mr. Tweedy (having untied himself and escaped the explosion unscathed) berates his wife for not listening to him about the chickens in the first place. This only enrages Mrs. Tweedy, but before she can lash out at her husband for his incompetence, a fed up Mr. Tweedy pushes the heavy barn door down on his wife after he finally had enough of his wife's abuse.
- Miranda Richardson appeared as the Witch in the 1988 episode "The Three Ravens" for the TV series "The Storyteller".
- Miranda Richardson appeared as Lady Van Tassel in the 1999 film "Sleepy Hollow".
- Miranda Richardson appeared as Queen Elspeth in the 2001 fantasy adventure television film "Snow White: The Fairest of Them All".