Madame Q. is the main antagonist of the 1990 arcade sidescrolling action game "Thunder Jaws" by Atari Games Corporation.
Seeking world domination, she abducts and transforms both human females and animals into mutants and cyborgs in her hidden underwater base. During the final battle, she becomes a mutant herself; a gigantic, monsterous head.
Arcade portrait.
CPC sprite
Arcade sprite
Amiga sprite
On the Atari ST box cover