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Karen Colfax (Sandra Kerns) was a minor villainess from "Habeas Corpses," the 16th episode of She-Wolf of London (alternately titled, Love and Curses; airdate March 13, 1991). She was the villainous ex-wife of Marty Colfax, who she catches with another woman, and had it videotaped to use as ammunition in their divorce battle. However, when Marty reveals that he's taking legal action against her, Karen revealed herself as a vampiress and attacked Marty.

When a dying Marty arrives at Ian and Randi's door, the pair see the bite marks and clearly suspect that a vampire is involved. They soon arrive at Karen's house posing as the actual owners, stating that Marty left them the house in his will. At that very moment, the evil Karen flashes her fangs and attempts to attack the pair, but she is killed by Ian, who plunged a "For Sale" sign through her heart.

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