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Elexis Sinclaire is the main antagonist in the cyberpunk-themed SiN series.

Elexis is a rich and powerful mad scientist who is secretly engaged in organized crime and planning to make a radical artificial evolutionary advance to the human race. She is the enemy of the games' protagonist, private security force commander John R. Blade. She was introduced in the video game SiN in 1998.

In the 2006 game SiN Episodes, her design was based on the model Bianca Beauchamp. Elexis is often perceived as one of the most sexual (either sexiest or most sexualized) female characters in video gaming, in the final cutscene of the original game she hints at showing John Blade her private parts just to buy enough time to make an escape.

Elexis is also the main antagonist in Sin: The Movie, an anime film produced by ADV Films along with Ritual Entertainment.

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