In London in 1957, a pair of Dalmatian dogs, Pongo (James Ludwig) and Missus (Catia Ojeda), live with their human owners, the Dearlys, and enjoy a happy life.
One day Missus gives birth to eight puppies, and the family is visited by Cruella De Vil, a former classmate of Mrs. Dearly (Kristen Beth Williams). Cruella tries to buy the litter, but Pongo and Missus' owners refuse to sell them.
Cruella hires two men, Jasper (Michael Thomas Holmes) and Jinx (Robert Anthony Jones), to kidnap the puppies, along with many other Dalmatians in the city, to make dog-skinned fur coats.
Pongo and Missus run away from home to find their puppies. With help from other dogs across the country, they find them, along with many other puppies, at Cruella's mansion and must get them back home without getting caught by the pursuing Cruella and her henchmen.
- Rachel York also played villainess Cassandra Hausen in the 2001 comedy romance TV movie Au Pair II.
- Rachel York was the voice of Circe in the 2004 episode "This Little Piggy", and the 2006 episode "Dead Reckoning" for the TV cartoon series "Justice League Unlimited".
- Rachel York appeared as villainess Carla Petro in the 2017 episode "Rekt in Real Life" for the TV series Elementary.