Evil women who take sexual pleasure in the pain and suffering of others. The villainess has to show obvious signs of being sexually aroused by the pain of others, examples include having an orgasm, masturbating or talking about how wet or turned on she is by it. A Sexual Sadist is also a Sadist by default.
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- Bambi and Barbi (Heavy Mental)
- Baroness Camilla (Superfumetti)
- Bezzie Powell (La Schiava)
- Christina (Starfuckers)
- Dr. Fletcher (Hellhole)
- Dr. Kisaragi (Corrupt Garden - Vore Predation)
- Genietta (Storie Viola)
- Helen Gifford and Kathy Reiner (Storie Blu)
- Hilde Schmittendorf (Dead Rising 3)
- Hypnotika (The Adventures Of O-Girl)
- Izzy Rogers (Criminal Minds)
- Jasmine (Crackerjack 2)
- Lady Winifred Dawncole (Calze Nere)
- Linda (Pornostar)
- Mabel (Storie Viola)
- Mara Schumer (Space Pirates)
- Margo Yeager (Sand Trap)
- Maria Cardenal (Matador)
- Miss Murdy (Lolita Story)
- Miss Polly (Lolita Story)
- Mutsu (Rougetsu Toshi)
- Olinka Casanova-Romanoff (Superfumetti)
- Persephone Trinh (Slasher)
- Princess Erzebeth (The Steel Trap Maiden)
- Quick Draw Mary (Western)
- Rachael/The Call Girl Killer (Creepshow III)
- Regina Lake (Il Marchese)
- Rei (Rougetsu Toshi)
- Samantha (The Hospital 2)
- Scorpion (Shin Cutie Honey)
- Sheila (Storie Blu Special)
- Thelma and Sophie (Pig)
- Trance (The Adventures Of O-Girl)
- Wanda Zilch (The Toxic Avenger)
- Xenia Onatopp (Goldeneye)
- Yaga (Playcolt)
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